abstract：OBJECTIVES:Ancillary molecular testing on tissue is available for mycobacterial disease; however, judicious use of highly sensitive tests, such as polymerase chain reaction (PCR) and sequencing, should be guided by histologic parameters. We sought to investigate the utility of performing acid-fast stains (AFS) on skin ...

journal_title：American journal of clinical pathology

authors： Laga AC,Milner DA Jr,Granter SR

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. METHODS:Forty-six cases of liposarcoma...

journal_title：American journal of clinical pathology

authors： Ware PL,Snow AN,Gvalani M,Pettenati MJ,Qasem SA

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinical utility of and demand for the creatine kinase (CK)-MB assay. METHODS:We examined the number of CK-MB tests from 2007 through 2013 while we progressively deemphasized their use. We first removed CK-MB from the acute coronary syndrome (ACS) panel and then from the main menu and observ...

journal_title：American journal of clinical pathology

authors： Singh G,Baweja PS

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To examine high expression of tumor necrosis factor ligand superfamily member 13 (TNFSF13), which is correlated with several malignancies. METHODS:TNFSF13 messenger RNA expression in tumor cells and fibroblasts in a cohort of patients with non-small cell lung cancer (NSCLC) was analyzed by quantitative real...

journal_title：American journal of clinical pathology

authors： Qian Z,Qingshan C,Chun J,Huijun Z,Feng L,Qiang W,Qiang X,Min Z

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:To examine laser microdissection and mass spectrometry (LMD-MS), which has emerged as a new tool to aid in typing amyloid proteins. RESULTS:ALECT-2 is a potential cause of hepatic amyloidosis best detected by LMD-MS. METHODS:One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chem...

journal_title：American journal of clinical pathology

authors： Damlaj M,Amre R,Wong P,How J

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:To evaluate cryoprecipitate and platelet ordering practices after the implementation of real-time clinical decision support systems (CDSSs) in a computerized physician order entry (CPOE) system. METHODS:Uniform platelet and cryoprecipitate transfusion thresholds were implemented at 11 hospitals in a regiona...

journal_title：American journal of clinical pathology

authors： Collins RA,Triulzi DJ,Waters JH,Reddy V,Yazer MH

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine if the Advia 2120 hematology analyzer (Siemens Healthcare Diagnostics, Deerfield, IL) can accurately quantify both WBCs and the proportion of neutrophils from synovial and ascitic body fluids. METHODS:We analyzed 60 samples on the Advia and compared the results wit...

journal_title：American journal of clinical pathology

authors： Froom P,Diab A,Barak M

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To review various anticoagulation therapies and related laboratory monitoring issues, with a focus on factor X-related chromogenic assays. METHODS:A case-based approach is used to review pertinent published literatures and product inserts of anticoagulation drugs and to look back on clinical use of factor X...

journal_title：American journal of clinical pathology

authors： Wool GD,Lu CM,Education Committee of the Academy of Clinical Laboratory Physicians and Scientists.

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To investigate metastasis associated in colon cancer 1 (MACC1) and MET expression in colorectal adenoma, Tis, early-stage invasive (T1 and T2), and advanced adenocarcinoma with liver metastasis using immunohistochemistry. METHODS:Ninety-three paraffin-embedded colorectal tumor specimens were immunohistochem...

journal_title：American journal of clinical pathology

authors： Ren B,Zakharov V,Yang Q,McMahon L,Yu J,Cao W

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). METHODS:We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast...

journal_title：American journal of clinical pathology

authors： Johnson RC,Savage NM,Chiang T,Gotlib JR,Cherry AM,Arber DA,George TI

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:To assess physicians' and nurses' satisfaction with the service provided by the laboratory at Gondar University Hospital. METHODS:We conducted a cross-sectional study involving 196 nurses and physicians. RESULTS:Overall level of satisfaction was 51.1% for nurses and 51.5% for physicians. Lack of consistenc...

journal_title：American journal of clinical pathology

authors： Addis Z,Birhan W,Derseh D,Sahle B,Gizaw N

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To correlate human herpesvirus 6 (HHV-6) viral load with pathologic features in graft acute hepatitis of unknown origin. METHODS:Liver frozen samples from 26 patients with graft hepatitis of unknown origin were available for HHV-6 DNA quantification. RESULTS:In 10 (38.5%) of 26 liver samples, HHV-6 DNA was...

journal_title：American journal of clinical pathology

authors： Buyse S,Roque-Afonso AM,Vaghefi P,Gigou M,Dussaix E,Duclos-Vallée JC,Samuel D,Guettier C

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

journal_title：American journal of clinical pathology

authors： Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:To calculate the incidence of nondiagnostic (ND) colorectal (CR) polyp cases in which deeper tissue sectioning rendered new diagnostic information--particularly adenomas--in 2 laboratories staffed by the same pathologists. METHODS:After initial diagnosis, 100 ND CR polyps from each laboratory were reexamine...

journal_title：American journal of clinical pathology

authors： Nielsen JA,Lager DJ,Lewin M,Weber JJ,Roberts CA

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:To describe our experience, both in meeting challenges and in reporting outcomes, of the consolidation of anatomic pathology services in the North Shore-LIJ Health System in February 2011. METHODS:We addressed issues of governance, personnel, physical plant, quality programming, connectivity, and education....

journal_title：American journal of clinical pathology

authors： Groppi DE,Alexis CE,Sugrue CF,Bevis CC,Bhuiya TA,Crawford JM

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:To identify, describe, and investigate the clinical, radiologic, and pathologic features of 8 cases of telangiectatic oncocytoma. METHODS:Fifty-three consecutive renal oncocytomas were reviewed for the telangiectatic pathologic features that were subsequently correlated with the demographic, clinical, and r...

journal_title：American journal of clinical pathology

authors： Xiao GQ,Ko HB,Unger P

更新日期：2013-07-01 00:00:00

abstract：:Ewing family tumors (EFTs) and prostate carcinomas are characterized by rearrangement of ETS genes, most commonly FLI1 (EFTs) and ERG (prostate carcinomas). Previously, we characterized an antibody against ERG (EPR3864) for detecting ERG-rearranged prostate carcinoma. Because EPR3864 also cross-reacts with FLI1, we ev...

journal_title：American journal of clinical pathology

authors： Tomlins SA,Palanisamy N,Brenner JC,Stall JN,Siddiqui J,Thomas DG,Lucas DR,Chinnaiyan AM,Kunju LP

更新日期：2013-06-01 00:00:00

abstract：:This report describes the clinical evaluation of a novel fluorescent immunoassay (FIA), Sofia Influenza A+B FIA (Quidel, San Diego, CA), for the rapid detection and differentiation of influenza A and B viruses. A total of 2,047 subjects provided nasal swabs and nasopharyngeal swabs or aspirates. The overall sensitivit...

journal_title：American journal of clinical pathology

authors： Lewandrowski K,Tamerius J,Menegus M,Olivo PD,Lollar R,Lee-Lewandrowski E

更新日期：2013-05-01 00:00:00

abstract：:An immunohistochemical study was conducted of 108 papillary carcinoma cases, including 48 cases with intratumoral heterotopic ossification (IHO). In 48 cases, papillary carcinoma with IHO was accompanied by nodular fibrosis. Cases of papillary carcinoma with IHO or nodular fibrosis showed higher incidences of lymph no...

journal_title：American journal of clinical pathology

authors： Takeda M,Mikami T,Numata Y,Okamoto M,Okayasu I

更新日期：2013-05-01 00:00:00

abstract：:The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lym...

journal_title：American journal of clinical pathology

authors： Sarantopoulos GP,Palla B,Said J,Kinney MC,Swerdlow SM,Willemze R,Binder SW

更新日期：2013-04-01 00:00:00

abstract：:The effectiveness of fine-needle aspiration (FNA) increases with the number of needle passes, but needle passes are also associated with increased risk of adverse events. The trade-off between needle passes and adequacy has not been well characterized. Clinical studies are limited because of their inherent variability...

journal_title：American journal of clinical pathology

authors： Schmidt RL,Kordy MA,Howard K,Layfield LJ,Hall BJ,Adler DG

更新日期：2013-03-01 00:00:00

abstract：:Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid pr...

journal_title：American journal of clinical pathology

authors： Wu J,Chu PG,Jiang Z,Lau SK

更新日期：2013-02-01 00:00:00

abstract：:Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the...

journal_title：American journal of clinical pathology

authors： Ross DS,Liu YF,Pipa J,Shin SJ

更新日期：2013-01-01 00:00:00

abstract：:Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings wi...

journal_title：American journal of clinical pathology

authors： Sutton B,Davion S,Feldman M,Siziopikou K,Mendelson E,Sullivan M

更新日期：2012-12-01 00:00:00

abstract：:We describe 41 cases of myeloid neoplasms (MNs) secondary to plasma cell myeloma (PCM). The types of MN included myelodysplastic syndrome (MDS) in 34 (82.9%), acute myeloid leukemia (AML) in 4 (9.8%), and myeloproliferative neoplasm (MPN) or MDS/MPN in 3 (7.3%) cases. The latency from treatment to diagnosis of MN rang...

journal_title：American journal of clinical pathology

authors： Reddi DM,Lu CM,Fedoriw G,Liu YC,Wang FF,Ely S,Boswell EL,Louissaint A Jr,Arcasoy MO,Goodman BK,Wang E

更新日期：2012-12-01 00:00:00

abstract：:We compared the anti-estrogen receptors (ER) SP1, 6F11, and 1D5 antibodies in breast carcinoma cases with different ranges of positive cells to evaluate whether this could generate different therapies for patients. We selected 66 cases of breast cancer, each of which was immunostained with the 3 antibodies. 1D5 was le...

journal_title：American journal of clinical pathology

authors： Bogina G,Zamboni G,Sapino A,Bortesi L,Marconi M,Lunardi G,Coati F,Massocco A,Molinaro L,Pegoraro C,Venturini M

更新日期：2012-11-01 00:00:00

abstract：:The use of direct thrombin inhibitors (DTIs) for prophylactic or therapeutic anticoagulation is increasing because of the predictable bioavailability and short half-life of these DTIs. However, in certain situations, indication of the concentration is warranted. We investigated the effects of 3 DTIs (lepirudin, argatr...

journal_title：American journal of clinical pathology

authors： Curvers J,van de Kerkhof D,Stroobants AK,van den Dool EJ,Scharnhorst V

更新日期：2012-10-01 00:00:00

abstract：:In today's environment, many laboratories and pathology practices are challenged to maintain or increase their quality while simultaneously lowering their overall costs. The cost of improving specimen processes is related to quality, and we demonstrate that actual costs can be reduced by designing "quality at the sour...

journal_title：American journal of clinical pathology

authors： Carlson RO,Amirahmadi F,Hernandez JS

更新日期：2012-09-01 00:00:00

abstract：:A variant hemoglobin fraction may be an incidental finding during HbA(1c) analysis using the G8 Tosoh HPLC analyzer, but it is unclear if the retention times and fraction patterns can reliably predict the findings of a high-performance liquid chromatography (HPLC) β-thalassemia program (Bio Rad Variant II analyzer). W...

journal_title：American journal of clinical pathology

authors： Froom P,Henig C,Zalman L,Barak M

更新日期：2012-09-01 00:00:00

abstract：:"Low-grade squamous intraepithelial lesion (LSIL), cannot exclude high-grade squamous intraepithelial lesion" (LSIL-H) is an increasingly used, equivocal interpretive category in gynecologic cytology. In an effort to evaluate its potential usefulness as a measure of quality assurance, we studied patterns of use of the...

journal_title：American journal of clinical pathology

authors： Nishino HT,Wilbur DC,Tambouret RH

更新日期：2012-08-01 00:00:00

abstract：:Lean methodologies have been applied in many industries to reduce waste. We applied Lean techniques to redesign laboratory workstations with the aim of reducing the number of times employees must leave their workstations to complete their tasks. At baseline in 68 workflows (aggregates or sequence of process steps) stu...

journal_title：American journal of clinical pathology

authors： Yerian LM,Seestadt JA,Gomez ER,Marchant KK

更新日期：2012-08-01 00:00:00

abstract：:This study aimed to ascertain pathologic findings of surgical follow-up excision (FUE) on patients who had radiologic finding of calcifications and lobular neoplasia (LN) on core biopsy. Breast core biopsy specimens from 2006-2011 with a diagnosis of pure classic-type LN (lobular carcinoma in situ [LCIS] and atypical ...

journal_title：American journal of clinical pathology

authors： Zhao C,Desouki MM,Florea A,Mohammed K,Li X,Dabbs D

更新日期：2012-07-01 00:00:00

abstract：:The t(3;21)(q26.2;q22) translocation is rare in cases of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). We studied 17 patients with MDS/AML associated with t(3;21) and compared them with 17 patients with MDS associated with inv(3) (q21q26.2)/t(3;3)(q21;q26.2), because these entities share 3q26 locus ...

journal_title：American journal of clinical pathology

authors： Li S,Yin CC,Medeiros LJ,Bueso-Ramos C,Lu G,Lin P

更新日期：2012-07-01 00:00:00

abstract：:To determine the performance and frequency of protein C reagents currently used by clinical laboratories, we analyzed North American Specialized Coagulation Laboratory Association (NASCOLA) protein C proficiency testing data from 6 surveys conducted in 2009 and 2010 (2009-1 to 2009-3 and 2010-1 to 2010-3). Interlabora...

journal_title：American journal of clinical pathology

authors： Baron JM,Johnson SM,Ledford-Kraemer MR,Hayward CP,Meijer P,Van Cott EM

更新日期：2012-06-01 00:00:00

abstract：:Gastric intraepithelial neoplasia (IEN; formerly dysplasia) is an advanced precancerous lesion. Lesions indefinite for IEN mimic the IEN phenotype but lack some morphologic attributes of IEN. Indefinite for IEN lesions may arise in native foveolae (atypical foveolar hyperproliferation [aFH]) or intestinalized glands (...

journal_title：American journal of clinical pathology

authors： Fassan M,Pizzi M,Farinati F,Nitti D,Zagonel V,Genta RM,Rugge M

更新日期：2012-05-01 00:00:00

abstract：:CD45/side scatter (SS) gating is widely used for isolating blasts by flow cytometry (FC). However, other cells contaminate the "blast gate" (BG); CD45/SS gating is thus imprecise, particularly when there are few blasts. We studied the BG contents in 21 myelodysplastic syndromes (MDSs), 14 myeloproliferative neoplasms ...

journal_title：American journal of clinical pathology

authors： Harrington AM,Olteanu H,Kroft SH

更新日期：2012-05-01 00:00:00

abstract：:Venous thromboembolism (VTE) results from the interaction of the Virchow triad (venous stasis, endothelial injury, and hypercoagulability). Risk factors for increased hypercoagulability, or thrombophilia, include activated protein C resistance/factor V Leiden, the prothrombin G20210A mutation, deficiencies of the natu...

journal_title：American journal of clinical pathology

authors： Ballard RB,Marques MB,Education Committee of the Academy of Clinical Laboratory Physicians and Scientists.

更新日期：2012-04-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are endemic in New York City hospitals and have been associated with serious infections globally. A real-time polymerase chain reaction (RT-PCR) assay was developed to detect carbapenem resistance attributable to KPC from blood culture bottles posi...

journal_title：American journal of clinical pathology

authors： Francis RO,Wu F,Della-Latta P,Shi J,Whittier S

更新日期：2012-04-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases with isolated trisomy 4. There were 9 men and 4 women with a media...

journal_title：American journal of clinical pathology

authors： Bains A,Lu G,Yao H,Luthra R,Medeiros LJ,Sargent RL

更新日期：2012-03-01 00:00:00

abstract：:We sought to characterize how well computerized "case flags" performed in evaluating critical diagnoses in anatomic pathology. All cases identified by a pathologist at sign-out and flagged as a critical diagnosis in anatomic pathology in 2 hospital laboratories during a 3-year period were reviewed. A subset of all cri...

journal_title：American journal of clinical pathology

authors： Renshaw A,Gould EW

更新日期：2012-03-01 00:00:00